The Seventh Sickle Cell Nephropathy

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Is renal medullary carcinoma the seventh nephropathy in sickle cell disease? A multi-center Nigerian survey.

INTRODUCTION Previous studies had enlisted renal medullary carcinoma (RMC) as the seventh nephropathy in sickle cell disease (SCD). Clinical experience has contradicted this claim and this study is targeted at refuting or supporting this assumption. OBJECTIVE To estimate the prevalence of RMC and describe other renal complications in SCD. MATERIALS AND METHODS 14 physicians (haematologists ...

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Sickle cell nephropathy.

Herrick [1] was the first to discover sickle cell hemoglobin ( 2 2) with sickle-shaped erythrocytes. In 1910, he described the case of a young black student from the West Indies with severe anemia characterized by “peculiar elongated and sickle-shaped red blood corpuscles.” Herrick also noted a slightly increased volume of urine of low specific gravity and thus observed the most frequent featur...

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DISEASE OF THE MONTH Sickle Cell Nephropathy

Epidemiology The presence of renal failure in sickle cell disease (SCD) ranges from 5 to 18% of the total population of SCD patients (1). Powars et al. (2), in a prospective, case-control study of patients with SCD compared with sickle cell hemoglobin C patients, documented 31 (4.2%) patients affected by renal failure. The median age at the time of renal failure was 23.1 yr. Survival time was 4...

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Sickle cell nephropathy - a practical approach.

Despite its apparently simple molecular aetiology, sickle cell disease (SCD) has long been known to have a remarkably variable clinical course, with complications involving many organs including the kidneys. Whilst many affected individuals show no evidence of renal involvement into late adulthood, others develop renal dysfunction in childhood or early adult life with a significant proportion e...

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ژورنال

عنوان ژورنال: Internal Medicine

سال: 2010

ISSN: 0918-2918,1349-7235

DOI: 10.2169/internalmedicine.49.4479